Proceedings of AllerGen 2019 Research Conference
Bibliographic record
Abstract
Background: Hemopoietic progenitor cells (HPC), both in the bone marrow and in peripheral tissues, differentiate into inflammatory effector cells and, thus, can modulate central and peripheral inflammation.There is growing evidence for the involvement of hemopoietic processes in the pathogenesis of atopy and asthma from pre-conception and birth.This is the basis for the "bone marrow" hypothesis of allergic disease, arguing that a perinatal environmental challenge leads to the skewed production and mobilization of HPC, regulating central and peripheral production of cell types that perpetuate allergic responses.The objective of this study was to assess the association of cell surface receptor profiles of cord blood (CB) HPC with atopy and allergic disease development and lung function at 1-and 3-years in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.Methods: We used flow cytometry to compare cytokine and toll-like receptor expression levels in CB HPC from infants who developed atopic sensitization (as assessed by positive skin prick test) at 1 and 3 years of age with healthy controls.We also compared the CB HPC receptor expression in relation to lung function as measured by lung clearance index (LCI) in the CHILD Study infants.Results: We found a significant increase in IL5RA-expressing HPC populations in the CB of cases at 1 and a trend towards increased IL17RBexpressing HPC in the CB of atopics at 1-year of age.Conversely, GM-CSFR-and ST2-expressing CB HPC were decreased in atopics both at 1-and 3-years.Additionally, there was evidence of infants with poor lung function at 3-years exhibiting higher IL5RA and IL17RB expression on the surface of CB HPC.Conclusions: This study provides evidence of pre-existing cellular alterations in infants' CB progenitors at birth, which herald the development of atopy/allergic disease and, potentially, future asthma.The observed pattern of receptor expression suggests Th2 skewing of CB HPC before the onset of allergic disease or measurable lung function deficits.Our results suggest that measurable immune cellular patterns at birth could be utilised to develop novel strategies for atopic/allergic disease interception in infants before disease onset.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.004 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.233 | 0.157 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".