Bibliographic record
Abstract
Intravenous injections of fresh human serum (FHS) with an operative alternative complement pathway (ACP) were toxic for mice. The toxic reaction was manifested by intravascular hemolysis, hemoglobinuria, and a slight prolongation in the mean activated thromboplastin time, prothrombin time and thrombin time. In moribund animals, this was followed by a profound thrombocytopenia and alterations in the leukocyte counts. Marked to slight leukopenia developed in animals dying relatively quickly, while leukocytosis was observed infrequently in animals dying after a protracted shock, and only in concurrence with hemoconcentration and thrombocytopenia. Although the latter sequence of events was not investigated extensively, it may have led to intravascular coagulation. During the acute phase of the reactions, the deposition of platelets mainly in the lungs, and erythrocytes mainly in the liver, was demonstrated by accumulation of radioactive labelling of platelets and erythrocytes, respectively. Histologic sections of the lung revealed hemorrhagic lesions and the accumulation of ‘platelet-like’ thrombi in the pulmonary vessels. The blood films of animals injected with active serum showed erythrocytes ghosts, but no hemagglutination or distinctive microangiopathic changes. The fatal consequence of serum injections could not be prevented by the administration of cortisone, histamine and serotonin antagonists, anticoagulants, or by β-adrenergic blockade. The injections of homologous erythrocytes lysed by human serum, but not of sonicated red cell, produced histopathologic lesions suggestive of disseminated intravascular coagulation (DIC) or thrombotic thrombocytopenic purpura (TTP) in the lungs. It is suggested that the interaction of complement and the coagulation system might induce the development of syndromes characterized by DIC or TTP, or thrombotic phenomena in other conditions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".