Effect Of Acute Exercise On Neutrophils In Children Receiving Maintenance Treatment For Acute Lymphoblastic
Bibliographic record
Abstract
Infectious complications of cancer treatment are potentially life threatening and remain a leading cause of morbidity and mortality in children diagnosed with cancer. There is substantial evidence to show that single bouts of exercise can produce relatively small but significant changes in the distribution and function of components of the immune system. To date, no study has examined the effects of acute exercise on neutrophils in patients with acute lymphoblastic leukemia (ALL) receiving maintenance therapy. PURPOSE To determine the effects of acute exercise on neutrophils in children receiving maintenance treatment for ALL compared to matched controls. METHODS Participants (n = 10; 4 ALL patients and 6 matched controls) were males between the ages of 7–18 years. On day 1, participants completed an incremental exercise test to exhaustion on a treadmill to determine peak aerobic fitness (VO2peak). On day 2, participants completed a 30-minute submaximal exercise test on a treadmill at 70% VO2peak with 4 blood sampling time points: pre exercise, post exercise, 1-hour post exercise and 2-hours post exercise. RESULTS Repeated measures analyses of variance demonstrated significant main effects for Time such that there was a significant increase in absolute neutrophil counts from pre exercise to post exercise [F (1,7) = 11.8; p=.011], a significant decrease from post exercise to 1-hour post exercise [F(1,7) = 5.9; p = .045], and a significant increase from 1-hour post exercise exercise to 2-hours post exercise [F(1,7) = 5.4; p = .052]. There were no main effects for Group and no Time by Group interactions (all ps >.100). The means and standard deviations for the ALL group were: pre exercise (M=3293; SD=1985), post exercise (M=4153; SD=2218), 1-hour post exercise (M=3199; SD=1274) and 2-hours post exercise (M=3498; SD=1358). The means and standard deviations for the control group were: pre exercise (M=2053; SD=898), post exercise (M=3022; SD=1294), 1-hour post exercise (M=2729; SD=1226) and 2-hours post exercise (M=3056; SD=1483). CONCLUSIONS This is the first study to investigate the effect of acute exercise on absolute neutrophil count in children with ALL receiving maintenance therapy. This pilot study demonstrates a similar neutrophil response in ALL patients as compared to matched controls with an increase following exercise. This finding may be of clinical importance for the ALL patient during periods of low immunity during maintenance treatment. At the least, it suggests that ALL patients on maintenance therapy do not have an adverse neutrophil response to an acute bout of30-minute moderate intencity exercice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".