Effect of Aerobic Exercise on Left Ventricular Diastolic Filling and Arterial Compliance in Older Hypertensives
Bibliographic record
Abstract
0583 Left ventricular diastolic dysfunction (LVDD) and impaired arterial compliance (IAC) may be subtle, early indices of vascular dysfunction with aging, sedentary lifestyle and hypertension. LVDD and IAC may impair exercise performance in those at risk who engage in therapeutic exercise training; while exercise testing may “unmask” LVDD and IAC among those starting such training programs and be used as a marker of risk improvement in addition to blood pressure lowering. PURPOSE: To evaluate the effect of aerobic exercise on LVDD and IAC in older hypertensive patients prior to starting and following an 8 week exercise training program. METHODS: Eight subjects participated in the study. Measures of LVDD (early filling flow velocity (E), late filling flow velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT)) and IAC (compliance (C) and distensibility (D) in carotid and brachial arteries) were assessed using VingMed-5 cardiac imaging system at rest before and following an 8 week exercise training program. RESULTS: LVDD indices (E, A, E/A, IVRT and DT) remained unaltered throughout the study (0.68 ± .13 vs 0.68 ± .15m/s, 0.82 ± .19 vs 0.89 ± .16m/s, 0.81 ± .24 vs 0.76 ± .05, 92.6 ± 1.0 vs 86.9 ± 7.6msec and 288.9 ± 59.6 vs 279.7 ± 75.1msec, respectively). None of IAC indices (C and D) in carotid artery changed during the exercise program (0.70 ± .12 vs 0.77 ± .08 cm2/mmHgx10−3, 0.18 ± .02 vs 0.24 ± .03 1/mmHgx10−2, respectively); however, IAC indices (C and D) in brachial artery changed significantly following the exercise program (0.20 ± .02 vs 0.29 ± .05 cm2/mmHgx10−3, 0.18 ± .02 vs 0.22 ± .02 1/mmHgx10−2, p<.05, respectively). CONCLUSION: These data suggest that in older hypertensives 8 week exercise training significantly improves the peripheral (brachial artery) artery compliance whereas no improvement in more “central” (left ventricle and carotid artery) artery compliance. Supported by A.M Anderson Award, Lawson Health Research Institute.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".