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Record W4255688238 · doi:10.1002/0470862106.ia470

Medicinal Inorganic Chemistry: An Introduction

2005· other· en· W4255688238 on OpenAlexaff
Katherine H. Thompson

Bibliographic record

VenueEncyclopedia of Inorganic Chemistry · 2005
Typeother
Languageen
FieldMedicine
TopicRadiopharmaceutical Chemistry and Applications
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsLanthanum carbonateChemistryCoordination complexNanotechnologyMaterials scienceHyperphosphatemiaMetalOrganic chemistry

Abstract

fetched live from OpenAlex

Abstract Metal ions in clinical use today include bismuth compounds, which have been in use for over a hundred years, lithium carbonate, which has been in use for over 50 years, and cisplatin, which was introduced almost 40 years ago. “Metals in medicine” also covers a wealth of newer diagnostic and therapeutic compounds, such as gadolinium‐based contrast agents for magnetic resonance imaging (MRI), samarium‐based compounds for relief of bone pain in intractable cancer, and lanthanum carbonate for the treatment of hyperphosphatemia. In the process, mystical/magical use of metals in medicine has given way to rational design and testing of new metallopharmaceutical compounds. Advances in our understanding of bioinorganic chemistry and increasingly sensitive analytical instrumentation enable an accelerated pace of development in medicinal inorganic chemistry.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.293
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0940.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.272
Teacher spread0.265 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2005
Admission routes1
Has abstractyes

Explore more

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