Monitoring vascular changes induced by photodynamic therapy using contrast-enhanced micro-computed tomography
Bibliographic record
Abstract
The aim of this study is to determine if contrast-enhanced micro-computed tomography can be used to non-invasively image the response of vasculature in tumours that have been treated with photodynamic theraphy (PDT). The subjects used were C3H mice with RIF-1 tumour implanted subcutaneously and allowed to grow for 3 weeks prior to treatment. The subjects in this study were divided into PDT treated groups (150 J/cm², 50 J/cm²) and control groups (150 J/cm² light-only, untreated). The contast-enhanced micro-computed tomography imaging procedure consisted of eight-second scans taking place before treatment and up to 24 hours after treatment. The treatment response was evaluated through the ration of blood-to-tumour volume. Significant changes were detected at 8 and 24 hours in the 150 J/cm² PDT group (p< 0.01). Immunohistochemical staining confirmed the effects of each treatment in comparison to the control groups.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".