Antihypertensive activity of secoisolariciresinol diglucoside (SDG) isolated from flaxseed: Role of guanylate cyclase
Bibliographic record
Abstract
Secoisolariciresinol diglucoside (SDG), a lignan isolated from flaxseed, is a phytoestrogen. Estrogens and phytoestrogen from soy have been reported to have mild hypotensive effects. Effects of SDG on arterial pressures are not known. The objective of this study was to determine whether (a) SDG has a hypotensive effect, and (b) the hypotensive effect is mediated through the L-arginine-nitric oxide pathway. The studies were conducted in anesthetized Sprague Dawley normotensive rats weighing between 450 and 500 grams Carotid arterial pressures were recorded to investigate the changes in the arterial pressures and heart rate with various doses of SDG. Maximum drops in the mean arterial pressure, which occurred at 15 minutes after intravenous SDG, were 40%, 41%, and 47%, respectively, with 10 mg, 15 mg, and 20 mg/kg of SDG. The pressures tended to recover, but even at the end of four hours, the percent drops in the mean arterial pressures were 33, 22, and 29, respectively, with 10 mg, 15 mg, and 20 mg/kg of SDG. The drops in the diastolic and mean arterial pressures were slightly higher than systolic pressures. Smaller doses of SDG (3 and 5 mg/kg) produced dose-dependent decreases in the systolic, diastolic, and mean arterial pressures. Heart rate remained unchanged. Pretreatment with N G -monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthase, did not prevent the SDG-induced reduction in arterial pressures. However, pretreatment with methylene blue (MB), a nonspecific, and oxadiazolo quinoxalin (ODQ), a specific inhibitor of guanylate cyclase, completely prevented the SDG-induced reduction in the arterial pressures. These results suggest that SDG is a long-acting hypotensive agent, and that the hypotensive effect is mediated through the guanylate cyclase enzyme.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".