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Record W4280516377 · doi:10.1016/j.ekir.2022.05.013

Pregnancy and Breastfeeding in Nephropathic Cystinosis With Native Kidneys

2022· article· en· W4280516377 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueKidney International Reports · 2022
Typearticle
Languageen
FieldMedicine
TopicBiomedical Research and Pathophysiology
Canadian institutionsAlberta Health ServicesUniversity of CalgaryWomen and Children’s Health Research InstituteUniversity of Alberta
Fundersnot available
KeywordsCystinosisCysteamineMedicineFanconi syndromePregnancyCystineInternal medicineTransplantationKidney transplantationEndocrinologyKidneyPediatricsBiochemistry

Abstract

fetched live from OpenAlex

Cystinosis is an autosomal recessive disorder causing deficiency of cystinosin, a lysosomal cystine transporter.1 Patients with cystinosis develop complications from cystine accumulation, such as Fanconi syndrome, progression to kidney failure, retinopathy, and endocrine disorders.2 Early and adequate cysteamine treatment, which reduces intracellular cystine levels, can reduce the rate of kidney disease progression.3 There are 11 published cases of cystinosis in pregnancy,4–7 10 in women who were dialysis-dependent or had undergone kidney transplantation before pregnancy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.127
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.282
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it