A case of carbidopa/levodopa associated colitis mimicking inflammatory bowel disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Carbidopa/levodopa is widely used in the management of Parkinson’s disease. We report a 77-year-old male with Parkinson’s disease who developed severe, protracted pancolitis and ileitis after 5-months of treatment with carbidopa/levodopa. The clinical presentation and endoscopic findings initially resembled acute infectious colitis and later inflammatory bowel disease. The patient was unresponsive to intravenous corticosteroids and biologic therapy. Biopsies showed severe colitis with some features suggesting a drug effect (e.g. prominent crypt apoptoses, attenuated and regenerating crypts, and crypt dropout). Discontinuation of carbidopa/levodopa was associated with clinical and endoscopic resolution of the colitis. Levodopa, in combination with benserazide was later re-introduced, without a recurrence of the patient’s gastrointestinal symptoms. We therefore propose carbidopa as the likely cause of colitis in this case.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it