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Record W4280646771 · doi:10.1016/s2214-109x(22)00199-1

Decoding the next SARS-CoV-2 variant

2022· letter· en· W4280646771 on OpenAlexaboutno aff
Jeremy Nel, François Venter

Bibliographic record

VenueThe Lancet Global Health · 2022
Typeletter
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsnot available
FundersNational Institutes of HealthMylanViiV HealthcareWellcome TrustUnited States Agency for International DevelopmentGilead SciencesMedical Research CouncilSouth African Medical Research CouncilSanofiBill and Melinda Gates Foundation
KeywordsScopusVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyDemographyMedicinePolitical scienceCoronavirus disease 2019 (COVID-19)MEDLINESociologyLawDisease

Abstract

fetched live from OpenAlex

What will the next SARS-CoV-2 variant bring to the world? Much mental horsepower has been dedicated to this question, ever since it became apparent in mid-2020 that the virus was far from settled into a stable evolutionary niche. The selection pressure on a virus is to generate as many onward infections as possible, whether through changes in its intrinsic transmissibility or through immune evasion. Sure enough, subsequent variants of concern have increased one or both parameters, with more recent variants being both more contagious and far better at evading antibody-driven responses from vaccines and earlier infection waves.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.011
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.072
Threshold uncertainty score0.142

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.011
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.002
Science and technology studies0.0010.000
Scholarly communication0.0040.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0140.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.152
GPT teacher head0.431
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2022
Admission routes1
Has abstractyes

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