Editorial: Molecular and Cellular Effectors in the Resolution of Inflammation
Bibliographic record
Abstract
Molecular and Cellular Effectors in the Resolution of InflammationAcute inflammation is broadly defined as a protective response of the organism to invading pathogens and tissue injury.The reaction should ideally be localized and self-limited, enabling the elimination of pathogens and damaged cells, and resolve on its own, leading to tissue repair and restoration of normal tissue and organ function (1).Uncontrolled or excessive inflammation or failure of the initial response to resolve in a timely manner leads to nonresolving inflammation, which is often chronic, or transient and relapsing (2).This ongoing low-grade inflammation is thought to fail to activate the integrated process of resolution (3), which is increasingly being recognized as a critical component of numerous prevalent human diseases, including atherosclerosis, arthritis, pulmonary diseases, autoimmunity, diabetes and cancer (2, 4).The inflammatory response is a complex process, heterogeneous in nature and depends on the type of disease and organ in which it occurs.The sequence of events and signaling circuits activated during the initiation and resolution phase have received considerable attention, and are summarized in guiding maps for inflammation (5) and resolution pathways (6).Resolution is an active process governed by endogenous resolution programs driven by specialized pro-resolving mediators (SPMs) acting at pro-resolving receptors (7).As an example, lipoxins synthesized from arachidonic acid during the resolution of self-limited inflammation function as stop signals through the receptor ALX/FPR2 for neutrophil recruitment, facilitate neutrophil apoptosis and efferocytosis (4), pivotal events in efficient resolution.Given the dual nature of inflammation and the importance of the inflammatory response in survival, it is paramount to develop new treatments to overcome the limitations of currently available antiinflammatory therapies, which are often accompanied with unwanted side effects and do not lead to repair of the affected tissues.Indeed, over the past few years a new branch of pharmacology termed "resolution pharmacology" (8, 9) has emerged, with the goal of developing strategies that promote resolution instead of blocking or inhibiting a mediator or pathway.This Research Topic brings together thirty-two articles, both reviews and original research papers, which highlight recent advances in resolution biology, wound repair, metabolic disorders, and acquired immunity using a large variety of experimental models.Twenty-four articles report
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.010 |
| Meta-epidemiology (narrow) | 0.005 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.003 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.003 | 0.003 |
| Scholarly communication | 0.007 | 0.006 |
| Open science | 0.005 | 0.001 |
| Research integrity | 0.012 | 0.016 |
| Insufficient payload (model declined to judge) | 0.028 | 0.025 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".