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Record W4281658853 · doi:10.1038/s41398-022-01963-5

Correction: Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial

2022· erratum· en· W4281658853 on OpenAlexaffabout
Arun K. Tiwari, Clement C. Zai, C. Anthony Altar, Julie‐Anne Tanner, Paige E. Davies, Paul Traxler, James Li, Elizabeth S. Cogan, Matthew Kucera, Ana Gugila, Nicole Braganza, Heather Emmerson, Gwyneth Zai, Daniel J. Müller, Robert D. Levitan, Stefan Kloiber, Zafiris J. Daskalakis, Benício N. Frey, James M. Bowen, Jean‐Éric Tarride, Richard Tytus, Ranjith Chandrasena, Nicholas Voudouris, Valerie H. Taylor, Raymond Tempier, Verinder Sharma, Akshya Vasudev, Peter Dzongowski, Lew Pliamm, Todd Greenspoon, Bryan Dechairo, James L. Kennedy

Bibliographic record

VenueTranslational Psychiatry · 2022
Typeerratum
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicPharmacogenetics and Drug Metabolism
Canadian institutionsHamilton Health SciencesParkwood InstituteUniversity of OttawaThornhill Medical (Canada)University of CalgaryImpactTed Rogers Centre for Heart ResearchWestern UniversityUniversity of TorontoMontfort HospitalUniversity Health NetworkCentre for Addiction and Mental HealthPrograms for Assessment of Technology in Health Research InstituteSt. Joseph’s Healthcare HamiltonMcMaster University
Fundersnot available
KeywordsRandomized controlled trialDepression (economics)MedicinePhysical therapyClinical trialDouble blindedPharmacogenomicsMedical physicsPsychologyPsychiatryAlternative medicineInternal medicinePlaceboPharmacologyPathology

Abstract

fetched live from OpenAlex

The original version of this article unfortunately contained mistakes. To ensure the accuracy of their article the authors would like to make the following corrections: Correction #1 Page 5, paragraph 1, line 5: Text currently reads “136”. This is incorrect and the authors are requesting to change it to “149”. Correction #2 Page 7, paragraph 4, line 17: Text currently reads “mild and moderately depressed patients”. This is incorrect and the authors are requesting to change it to: “patients with no or mild depression”. Correction #3 Supplementary Materials, Supplementary Table 2: The following Antipsychotic medications are incorrectly listed under Antidepressants: Olanzapine, Paliperidone, Perphenazine, Quetiapine, Risperidone, Thiothixene, Ziprasidone. The authors are requesting to update Supplementary Table 2 to include the above Antipsychotic medications in the Antipsychotic medication section of the table. The authors apologize for the errors. The original article has been corrected accordingly.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.794
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.004
Insufficient payload (model declined to judge)0.0060.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.101
GPT teacher head0.424
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2022
Admission routes2
Has abstractyes

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