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Magnetic Nanoparticles for Imaging, Diagnosis, and Drug-Delivery Applications

2022· book-chapter· en· W4282917495 on OpenAlexaff
Ejlal Abu‐El‐Rub, Hana M. Zegallai, Basma Milad Aloud, Saravanan Sekaran, Donald W. Miller

Bibliographic record

VenueBENTHAM SCIENCE PUBLISHERS eBooks · 2022
Typebook-chapter
Languageen
FieldMaterials Science
TopicNanoparticle-Based Drug Delivery
Canadian institutionsUniversity of Manitoba
Fundersnot available
KeywordsDrug deliveryMagnetic nanoparticlesNanotechnologyMagnetic resonance imagingTargeted drug deliveryNanoparticleStem cellMaterials scienceBiomedical engineeringMedicineBiologyRadiologyCell biology

Abstract

fetched live from OpenAlex

Magnetic Nanoparticles (MNPs) have gained interest within the research community due to their therapeutic potential in a variety of medical applications. MNPs are generally composed of a metallic core stabilized by the addition of an outer shell that can be further functionalized through the absorbance or conjugation of various targeting ligands. The magnetic properties of these nanoparticles can be utilized for imaging, localized drug delivery, and enhanced diagnostic detection. This chapter highlights the applications of MNPs to enhance magnetic resonance imaging (MRI) capabilities and improve the delivery of therapeutic agents to difficult-to-reach areas in the body. In addition, recent advances in the use of MNPs in stem cell therapy for both the tracking and monitoring of stem cell distribution in the body and improving engraftment and differentiation in stem cell therapy are discussed. Finally, examples of the incorporation of MNPs in diagnostic assays to improve rapid and realtime detection capabilities of many diseases, including cancer, cardiovascular diseases, and pathogen infections, are provided.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.025
Threshold uncertainty score0.085

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0250.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.229
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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