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Record W4283162280 · doi:10.1002/hbm.25977

Allometry in the corpus callosum in neonates: Sexual dimorphism

2022· article· en· W4283162280 on OpenAlexafffund
John D. Lewis, Henriette Acosta, Jetro J. Tuulari, Vladimir Fonov, D. Louis Collins, Noora M. Scheinin, Satu J. Lehtola, Aylin Rosberg, Kristian Lidauer, Elena Ukharova, Jani Saunavaara, Riitta Parkkola, Tuire Lähdesmäki, Linnéa Karlsson, Hasse Karlsson

Bibliographic record

VenueHuman Brain Mapping · 2022
Typearticle
Languageen
FieldMedicine
TopicFetal and Pediatric Neurological Disorders
Canadian institutionsMcGill UniversityMontreal Neurological Institute and Hospital
FundersTurun YliopistosäätiöNatural Sciences and Engineering Research Council of CanadaJuho Vainion SäätiöVarsinais-Suomen SairaanhoitopiiriSigne ja Ane Gyllenbergin SäätiöSigrid Juséliuksen SäätiöEmil Aaltosen SäätiöLastentautien TutkimussäätiöAcademy of FinlandCanadian Institutes of Health ResearchCompute CanadaJane ja Aatos Erkon SäätiöYrjö Jahnssonin SäätiöNational Alliance for Research on Schizophrenia and Depression
KeywordsAllometrySexual dimorphismCorpus callosumBiologyBrain sizeSex characteristicsLateralization of brain functionZoologyPhysiologyAnatomyNeuroscienceEndocrinologyEcologyMedicineMagnetic resonance imaging

Abstract

fetched live from OpenAlex

The corpus callosum (CC) is the largest fiber tract in the human brain, allowing interhemispheric communication by connecting homologous areas of the two cerebral hemispheres. In adults, CC size shows a robust allometric relationship with brain size, with larger brains having larger callosa, but smaller brains having larger callosa relative to brain size. Such an allometric relationship has been shown in both males and females, with no significant difference between the sexes. But there is some evidence that there are alterations in these allometric relationships during development. However, it is currently not known whether there is sexual dimorphism in these allometric relationships from birth, or if it only develops later. We study this in neonate data. Our results indicate that there are already sex differences in these allometric relationships in neonates: male neonates show the adult-like allometric relationship between CC size and brain size; however female neonates show a significantly more positive allometry between CC size and brain size than either male neonates or female adults. The underlying cause of this sexual dimorphism is unclear; but the existence of this sexual dimorphism in neonates suggests that sex-differences in lateralization have prenatal origins.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.044
GPT teacher head0.273
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2022
Admission routes2
Has abstractyes

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