P.104 Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain
Bibliographic record
Abstract
Background: Adult neurogenesis occurs in the hippocampus and the subventricular zone. Recent evidence suggests that neurogenesis may also extend to other brain regions (hypothalamus, striatum, substantia nigra, cortex, and amygdala). Harnessing this intrinsic neurogenic potential may present a novel alternative for the replenishment of neurons lost in neurologic conditions. Methods: This descriptive review summarizes evidence supporting the classic and novel neurogenic zones present within the mammalian brain, discusses the functional significance of these new neurons, and the potential clinical applications of promoting intrinsic neurogenesis. Results: Some studies suggest new neurons originate from endogenous stem cell pools located within novel neurogenic regions while others show the migration from the subventricular zone to these regions. Regardless, adult neurogenesis is impacted by neurologic processes such as ischemia and neurodegenerative diseases and can be modulated by factors including neurotrophins, pharmacologic interventions, environmental exposures, exercise, and stem cell therapy. Conclusions: The discovery of functionally significant neurogenesis in adult brain regions has implications not only with regards to the function of these regions, but also for neuropathological conditions that affect them. Pharmacologic and stem cell-based strategies capable of promoting neurogenesis may have therapeutic potential following stroke or in the context of various neurodegenerative disorders.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.026 | 0.009 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".