Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate
Bibliographic record
Abstract
The intervertebral disc (IVD) is a complex structure, and recent evidence suggests that separations or delamination between layers of the annulus may contribute to degeneration development, a common cause of low back pain The purpose of the present experiment was to quantify the mechanical response of the layer-adjoining interlamellar matrix at different rates of separation. Understanding the rate-dependency of the interlamellar matrix, or the adhesion between adjacent layers of the disc, is important as the spine experiences various loading velocities during activities of daily living. Twelve discs were dissected from four bovine tails (three extracts per tail). Two multi-layered annulus samples were collected from each IVD (total = 24, mean bond width = 3.82 ± 0.96 mm) and randomly assigned to a 180° peel test at one of three delamination rates; 0.05 mm/s, 0.5 mm/s, or 5 mm/s. Annulus extracts were found to have similar maximal adhesion strengths ( p = 0.39) and stiffness ( p = 0.97) across all rate conditions. However, a significant difference in lamellar adhesion strength variability was observed between the 5 mm/s condition (0.96 N/mm ± 0.31) when compared to the 0.5 mm/s (0.50 N/mm ± 0.19) and 0.05 mm/s (0.37 N/mm ± 0.13) conditions ( p < 0.05). Increased variability may be indicative of non-uniform strength due to inconsistent adhesion throughout the interlamellar matrix, which is exacerbated by increased rates of loading. The observed non-uniform strength could possibly lead to a scenario more favourable to the development of microtrauma, and eventual delamination.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".