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Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David C. Perry, Paul Aisen, Arthur W. Toga, Gustavo Jiménez, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Paul Aisen, Ronald Petersen, Clifford R. Jack, Matt A. Bernstein, Bret Borowski, Jeff Gunter, Matthew L. Senjem, Prashanthi Vemuri, David T. Jones, Kejal Kantarci, Chad Ward, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, William J. Jagust, Susan Landau, John Q. Trojanowki, Leslie M. Shaw, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher Clark, Steven E. Arnold, Virginia M.‐Y. Lee, Magdalena Korecka, Michal Figurski, Laurel Beckett, Danielle Harvey, Charles DeCarli, Evan Fletcher, Pauline Maillard, John Olichney, Owen Carmichael, Robert C. Green, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Andrew J. Saykin, Tatiana Foroud, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, John C. Morris, Marc Raichle, David M. Holtzman, Nigel J. Cairns, Erin Franklin, Lisa Taylor‐Reinwald, Beau M. Ances, David Winkfield, Maria Carroll, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, Lew Kuller, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Steven M. Paul, Norman Relkin, Gloria Chiang, Michael Lin, Lisa Ravdin, Peter J. Davies, M. Marcel Mesulam, Marek-Marsel Mesulam, Emily Rogalskı, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy E. Johnson, Peter J. Snyder, Tom Montine, Lean Thal, James B. Brewer, Helen Vanderswag, Adam Fleisher, Paul M. Thompson, Ellen Woo, Daniel Silverman, Edmond Teng, Sarah Kremen, Liana Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Robert A. Koeppe, Jaimie Ziolkowski, Judith L. Heidebrink, Joanne Lord, Norm Foster, Marilyn Albert, Chiadi U. Onyike, Daniel D’Agostino, Stephanie Kielb, Joseph F. Quinn, Lisa C. Silbert, Betty Lind, Jeffrey Kaye, Raina Carter, Sara Dolen, Javier Villanueva‐Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Randy Yeh, Daniel Marson, David Geldmacher, Marissa Natelson, Randall Griffith, David Clark, John Brockington, Hillel Grossman, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Martin Sadowski, Mohammed O. Sheikh, Jamika Singleton-Garvin, Anaztasia Ulysse, Mrunalini Gaikwad, P. Murali Doraiswamy, Olga James, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Riham El Khouli, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Kim Martin, Nancy Kowalksi, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Steven Potkin, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Christopher H. van Dyck, Richard E. Carson, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Ntekim E. Oyonumo, Joanne Allard, Olu Ogunlana, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Jerome A. Yesavage, Joy L. Taylor, Steven Chao, Barton Lane, Allyson Rosen, Jared Tinklenberg, Douglas W. Scharre, Maria Kataki, Rawan Tarawneh, Earl A. Zimmerman, Dzintra Celmins, David Hart, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Mia Yang, Akiva Mintz, Del D. Miller, Karen Ekstam Smith, Hristina Koleva, Ki Won Nam, Hyungsub Shim, Susan K. Schultz, Amanda Smith, Christi Leach, Balebail Ashok Raj, Kristin Fargher, Eric M. Reiman, Kewei Chen, Pierre N. Tariot, Anna Burke, Joel Hetelle, Kathryn DeMarco, Nadira Trncic, Stephanie Reeder, Edward Zamrini, Christine M. Belden, Sherye A. Sirrel, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Charles Bernick, Donna Munic, Zaven S. Khachaturian, Neil Buckholtz, John Hsiao, William Z. Potter, Howard Fillit, Franz Hefti, Carl Sadowsky, Teresa Villena, Ging‐Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Stephen Pasternack, William Pavlosky, Irina Rachinsky, Andrew Kertesz, Sandra E. Black, Bojana Stefanovic, Chrinthaka Heyn, Brian R. Ott, Geoffrey Tremont, Lori A. Daniello, Courtney Bodge, Stephen Salloway, Paul Malloy, Stephen Correia, Athena Lee, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Vernice Bates, Horacio Capote, Michelle Rainka, Jacobo Mintzer, Kenneth Spicer, David Bachman, John Rogers, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Smita Kittur, Michael Borrie, T.-Y. Lee, Robert Bartha, Richard Frank, Nick C. Fox, Veronika Logovinsky, Maria Corrillo, Greg Sorensen, Xiaofeng Zhu, Xinglong Wang
Bibliographic record
VenueNature Communications · 2022
Typeerratum
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsSt Joseph's Health CareSunnybrook Health Science CentreSt Joseph's Health CentreMcGill UniversityJewish General Hospital
Fundersnot available
KeywordsDiseaseComputational biologyNeuroscienceMedicineBiologyCell biologyPathology
Abstract
In the original version of the manuscript, the image shown in Figure 4g, bottom row (Aβ1–42 + rAggregatin), under “6h” was incorrect. This image incorrectly showed the same sample as shown in the original Figure 4g, top row (Aβ1–42), under “0.5h”.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.031
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.055
Threshold uncertainty score0.183
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.031 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.005 | 0.008 |
| Insufficient payload (model declined to judge) | 0.055 | 0.031 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.064
GPT teacher head0.397
Teacher spread0.332 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations0
Published2022
Admission routes1
Has abstractyes