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Record W4285397979 · doi:10.1149/ma2022-01502121mtgabs

Controlling DNA Spacing in a Monolayer, Using DNA Nano-Cubes

2022· article· en· W4285397979 on OpenAlexaff
Adrian Grzedowski, Tianxiao Ma

Bibliographic record

VenueECS Meeting Abstracts · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdvanced biosensing and bioanalysis techniques
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMonolayerNanotechnologyBiosensorFluorescenceDNAAtomic force microscopyDNA origamiMaterials scienceNano-Surface modificationSelf-assembled monolayerFluorescence microscopeNanostructureChemistryOpticsPhysicsBiochemistryPhysical chemistry

Abstract

fetched live from OpenAlex

DNA SAMs have received a lot of research interest recently as a suitable platform for modern biosensors. However, there are some shortcomings that remain to be addressed, such as uneven coverage of monolayer, or the spacing between the DNA strands that is hard to control. Here, we present DNA nanostructured cubes as an improved platform for DNA SAM based sensors. The DNA nano-cubes allow for a precise control of ssDNA spacing on the surface and have a great functionalization possibility. We have modified the nanostructures to include thiolated surface anchor and a fluorescence reporter. Cubes were deposited gold electrode via Au-S bonds and analyzed, using AFM and in-situ fluorescence microscopy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.265
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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