Comparison of machine learning and the regression-based EHMRG model for predicting early mortality in acute heart failure
Bibliographic record
Abstract
BACKGROUND: Although risk stratification of patients with acute decompensated heart failure (HF) is important, it is unknown whether machine learning (ML) or conventional statistical models are optimal. We developed ML algorithms to predict 7-day and 30-day mortality in patients with acute HF and compared these with an existing logistic regression model at the same timepoints. METHODS: Patients presenting to one of 86 hospitals, who were either admitted to hospital or discharged home directly from the emergency department, were randomly selected using stratified random sampling. ML approaches, including neural networks, random forest, XGBoost, and the Lasso, were compared with a validated logistic regression model for discrimination and calibration. RESULTS: Among 12,608 patients in our analysis, lasso regression (c-statistic 0.774; 95% CI, 0.743, 0.806) performed better than other ML models for 7-day mortality but did not outperform the baseline logistic regression model (0.794; 95% CI, 0.789, 0.800). For 30-day mortality, XGBoost performed better than other ML models (c-statistic 0.759; 95% CI; 0.740, 0.779), but was not significantly better than logistic regression (c-statistic 0.755; 95% CI, 0.750, 0.762). Logistic regression demonstrated better calibration at 7 days (calibration-in-the-large 0.017; 95% CI, -0.657, 0.692, and calibration slope 0.954; 95% CI, 0.769, 1.139), and at 30 days (-0.026; 95% CI, -0.374, 0.322, and 0.964; 95% CI, 0.831, 1.098), and best Brier scores, compared to ML approaches. CONCLUSIONS: Logistic regression was comparable to ML in discrimination, but was superior to ML algorithms in calibration overall. ML algorithms for prognosis should routinely report calibration metrics in addition to discrimination.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.012 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".