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Record W4288096403 · doi:10.1101/2022.07.26.501597

Rhizospheric miRNAs affect the plant microbiota

2022· preprint· en· W4288096403 on OpenAlexafffund
Harriet Middleton, Jessica Dozois, Cécile Monard, Virginie Daburon, Emmanuel Clostres, Julien Tremblay, Jean‐Philippe Combier, Étienne Yergeau, Abdelhak El Amrani

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2022
Typepreprint
Languageen
FieldAgricultural and Biological Sciences
TopicPlant Molecular Biology Research
Canadian institutionsNational Research Council CanadaInstitut National de la Recherche Scientifique
FundersFonds de recherche du Québec – Nature et technologiesNatural Sciences and Engineering Research Council of CanadaInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementCentre National de la Recherche ScientifiqueNational Research Council CanadaCompute Canada
KeywordsRhizosphereBiologyBrachypodium distachyonArabidopsisArabidopsis thalianamicroRNABacteriaBotanyGeneMutantGeneticsGenome

Abstract

fetched live from OpenAlex

Abstract Recently, small RNAs have been shown to play important roles in cross-kingdom communication, notably in plant-pathogen relationships. Plant miRNAs were even shown to regulate gene expression in the gut microbiota. But what impact do they have on the plant microbiota? Here we hypothesized that plant miRNAs can be found in the rhizosphere of plants, where they are taken up by rhizosphere bacteria, influencing their gene expression, thereby shaping the rhizosphere bacterial community. We found plant miRNAs in the rhizosphere of Arabidopsis thaliana and Brachypodium distachyon . These plant miRNAs were also found in rhizosphere bacteria, and fluorescent synthetic miRNAs were taken up by cultivated bacteria. A mixture of five plant miRNAs modulated the expression of more than a hundred genes in Variovorax paradoxus , whereas no effect was observed in Bacillus mycoides . Similarly, when V. paradoxus was grown in the rhizosphere of Arabidopsis that overexpressed a miRNA, it changed its gene expression profile. The rhizosphere bacterial communities of Arabidopsis mutants that were impaired in their miRNA or small RNA pathways differed from wildtype plants. Similarly, bacterial communities of Arabidopsis overexpressing specific miRNAs diverged from control plants. Finally, the growth and the abundance of specific ASVs of a simplified soil community were affected by exposure to a mixture of synthetic plant miRNAs. Taken together, our results support a paradigm shift in plant-bacteria interactions in the rhizosphere, adding miRNAs to the plant tools shaping microbial assembly.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.214
Teacher spread0.194 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2022
Admission routes2
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicPlant Molecular Biology Research→French-language works237,207→