Editorial: Signaling in stress sensing and resistance in parasitic protozoa
Bibliographic record
Abstract
Signaling in stress sensing and resistance in parasitic protozoaProtozoan parasites are a large and highly diverse group of unicellular eukaryotes infecting humans and animals, posing enormous health and socio-economic impacts.More than 1 million deaths annually are caused globally by protozoan parasites (Andrews et al., 2014).A significant proportion of the world population is at risk of being afflicted by parasitic diseases like malaria, African trypanosomiasis, Chagas disease, and leishmaniases, widely considered "Neglected global infectious diseases" for which the dearth of clinically approved vaccines and safer and efficacious chemotherapeutic options (https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1)still persists.Protozoan pathogens lead complex life cycles, from one host to another, surviving in a variety of morphotypic forms through this complex continuum.The developmental stages can be free-living, extracellular parasitic or intracellular parasitic.The key trigger identified for such transitions has often been stresses such as the alteration of temperature or pH, hypoxia, oxidative burst, or nutrient depletion (Vonlaufen et al., 2008).Of note, stress-associated modulations confer endurance to drug exposure to augment resistance or develop quiescent or 'persister-like' forms.Hence, the ability to sense and respond to stress and thrive in less than optimal conditions, hence, are crucial for pathogenicity of the parasites, manifestation of diseases and for combating chemotherapeutic challenge (Bhattacharya et al., 2020).Some of the major stressresponse pathways, characterized to date, are elicited by posttranslational modifications (PTM), redox systems, chaperon proteins that mediate protein folding and secondary messengers like cyclic adenosine monophosphate or calcium (cAMP or Ca 2+ ) which modulate chemotaxis, antioxidant defence of the parasite (Kelly et al., 2021;Quintana et al., 2021).Against this backdrop, the primary goal of the Research Topic has been to envision the link between adaptive stress response with pathogenicity and drug Frontiers in Cellular and Infection Microbiology frontiersin.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.012 |
| Meta-epidemiology (narrow) | 0.004 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.003 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.003 | 0.003 |
| Scholarly communication | 0.006 | 0.006 |
| Open science | 0.004 | 0.001 |
| Research integrity | 0.013 | 0.016 |
| Insufficient payload (model declined to judge) | 0.023 | 0.019 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".