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Record W4289262469 · doi:10.21203/rs.3.rs-1889042/v1

Exposure to maternal diabetes during pregnancy is associated with worse short-term neonatal and neurological outcomes following perinatal hypoxic-ischemic encephalopathy

2022· preprint· en· W4289262469 on OpenAlexaff
Nancy Laval, Mariane Paquette, Hamza Talsmat, Bohdana Marandyuk, Pia Wintermark, Ala Birca, Elana Pinchefsky, Sophie Tremblay

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldMedicine
TopicGestational Diabetes Research and Management
Canadian institutionsCentre Hospitalier Universitaire Sainte-Justine
Fundersnot available
KeywordsMedicineEncephalopathyDiabetes mellitusNeonatal intensive care unitHypoxic Ischemic EncephalopathyPediatricsNeonatal encephalopathyPregnancyGestational diabetesGestational ageGestationInternal medicineEndocrinology

Abstract

fetched live from OpenAlex

Abstract Background Infants of diabetic mothers are at higher risk of perinatal morbidities but the impact of maternal diabetes on neonatal and neurological outcomes of neonates with hypoxic-ischemic encephalopathy (HIE) remains poorly described. Objectives To determine the association between maternal diabetes with outcomes following HIE. Methods A retrospective study including term neonates with HIE who received therapeutic hypothermia treatment between 2013–2020. Results Neonates with HIE and maternal diabetes exposure had lower gestational age at birth (P = 0.005) and higher birth weight (P = 0.012). Infants of diabetic mothers were ventilated longer (P = 0.0047) and had a longer neonatal intensive care unit (NICU) stay (P = 0.0483) as well as longer time to reach full oral feed (P = 0.0432). Maternal diabetes was associated with increased risk of death or abnormal neurological examination at discharge in neonates with HIE (OR 6.41). Conclusion In neonates with HIE, maternal diabetes is associated with an increased risk of death or short-term neonatal morbidities.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.337
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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