Coupling of the spatial distributions between sMRI and PET reveals the progression of Alzheimer’s disease
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Bibliographic record
Abstract
Abstract Amyloid-beta (Aβ) deposition and altered brain structure are the most relevant neuroimaging biomarkers for Alzheimer’s disease (AD). However, their spatial inconsistency was always confusing and misleading. Furthermore, the relationship between this spatial inconsistency and AD progression is unclear. The current study introduced a regional radiomics similarity network (R2SN) to map structural MRI and Aβ positron emission tomography (PET) images to study their cross-modal interregional coupling. A total of 790 participants (248 normal controls, 390 mild cognitive impaired patients, and 152 AD patients) with their structural MRI and PET images were studied. The results showed that global and regional R2SN coupling significantly decreased according to the severity of cognitive decline, from mild cognitive impairment to AD dementia. The global coupling patterns are discriminative between different APOE ε4, Aβ, and Tau subgroups. R2SN coupling was probed for relationships with neuropsychiatric measures and peripheral biomarkers. Kaplan–Meier analysis showed that lower global coupling scores could reveal worse clinical progression of dementia. The R2SN coupling scores derived from the coupling between Aβ and atrophy over individual brain regions could reflect the specific pathway of AD progression, which would be a reliable biomarker for AD.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it