Summary of the National Advisory Committee on Immunization (NACI) Rapid Response—Interim guidance on the use of Imvamune in the context of monkeypox outbreaks in Canada
Bibliographic record
Abstract
Background: , a live, non-replicating smallpox vaccine, was approved by Health Canada for active immunization against smallpox and monkeypox infections and disease in adults determined to be at high risk for exposure. The aim of this interim guidance is to consider the use of Imvamune for post-exposure prophylaxis (PEP) and to summarize the available evidence in support of Imvamune use in this specific current context. Methods: The National Advisory Committee on Immunization (NACI) High Consequence Infectious Disease Working Group (HCID WG) reviewed data on the current status of the monkeypox outbreak, along with additional evidence included in published scientific literature and from manufacturers, regarding the safety, immunogenicity and protection offered by Imvamune. NACI approved these HCID WG recommendations on June 8, 2022. Results: In brief, NACI recommends that PEP, using a single dose of the Imvamune vaccine, may be offered to individuals with high-risk exposures to a probable or confirmed case of monkeypox, or within a setting where transmission is happening. After 28 days, if an individual is assessed as having a predictable ongoing risk of exposure, a second dose may be offered. Imvamune may be offered to special populations; including individuals who are immunosuppressed, pregnant, breastfeeding, younger than 18 years of age and/or with atopic dermatitis. Conclusion: NACI has rapidly developed guidance on the use of Imvamune in Canada in the context of many uncertainties. Recommendations may be revisited as new evidence emerges.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".