The Short-term Effect of Consecutive Platelet-rich Plasma Injections on Chronic Pain in Knee Osteoarthritis
Bibliographic record
Abstract
Objective: Osteoarthritis (OA) is a joint disease that occurs because of various reasons that cause the imbalance between destruction and repair in the joint cartilage and subchondral bone. The purpose of platelet-rich plasma (PRP) in knee OA is to increase cartilage regeneration owing to the growth factors it contains. This study measured the short-term efficacy of consecutive PRP injections in patients with OA of the knee. Methods: Patients with Kellgren-Lawrence (KL) stage 2-4 knee OA were included in the study. Three sessions of PRP injections at 2-week intervals were applied to 78 knees of 55 patients. The visual analog scale was used on day 0, week 4 and week 16 to assess pain. Additionally, the functional status was measured by Western Ontario and McMaster Universities OA index which contains pain, stiffness and disability sub-scores. Results: Of the 55 patients, 45 were female. The mean age was 59.49.4 years. A total of 22 patients had bilateral knee involvement, and 51 of the 78 knee joints were classified as KL grade 3-4 OA and the other 27 knee joints were classified as KL grade 2. Conclusion: It was shown that PRP injection was effective on pain and limitation of movement in knee OA for 16 weeks. Also, it has been noted that early injections provide a more significant reduction in pain in knee OA.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".