An Integrative Genomic Prediction Approach for Predicting Buffalo Milk Traits by Incorporating Related Cattle QTLs
Bibliographic record
Abstract
Background: The 90K Axiom Buffalo SNP Array is expected to improve and speed up various genomic analyses for the buffalo (Bubalus bubalis). Genomic prediction is an effective approach in animal breeding to improve selection and reduce costs. As buffalo genome research is lagging behind that of the cow and production records are also limited, genomic prediction performance will be relatively poor. To improve the genomic prediction in buffalo, we introduced a new approach (pGBLUP) for genomic prediction of six buffalo milk traits by incorporating QTL information from the cattle milk traits in order to help improve the prediction performance for buffalo. Results: In simulations, the pGBLUP could outperform BayesR and the GBLUP if the prior biological information (i.e., the known causal loci) was appropriate; otherwise, it performed slightly worse than BayesR and equal to or better than the GBLUP. In real data, the heritability of the buffalo genomic region corresponding to the cattle milk trait QTLs was enriched (fold of enrichment > 1) in four buffalo milk traits (FY270, MY270, PY270, and PM) when the EBV was used as the response variable. The DEBV as the response variable yielded more reliable genomic predictions than the traditional EBV, as has been shown by previous research. The performance of the three approaches (GBLUP, BayesR, and pGBLUP) did not vary greatly in this study, probably due to the limited sample size, incomplete prior biological information, and less artificial selection in buffalo. Conclusions: To our knowledge, this study is the first to apply genomic prediction to buffalo by incorporating prior biological information. The genomic prediction of buffalo traits can be further improved with a larger sample size, higher-density SNP chips, and more precise prior biological information.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".