Polymer dots and glassy organic dots using dibenzodipyridophenazine dyes as water-dispersible TADF probes for cellular imaging
Bibliographic record
Abstract
]phenazine-12-yl (BPPZ) motif, and demonstrate two parallel approaches for the encapsulation of these fluorophores to yield water-dispersible nanoparticles suitable for TRFI. First, fluorescent polymer dots (Pdots) were formed by dye encapsulation within cell-penetrating amphiphilic copolymers. Glassy organic nanoparticles (g-Odots) were also prepared, giving nanoparticles with higher photoluminescence quantum yields and improved colour purity. Both approaches yielded nanoparticles suitable for imaging, with reasonable uptake and cytotoxicity on the timescale of standard imaging experiments using human cervical (HeLa) and liver (HepG2) cancer cell lines. This work demonstrates two flexible strategies for preparing water-dispersible TADF nanoparticles for TRFI, both of which should be readily adaptable to nearly any existing hydrophobic TADF dye.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".