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Record W4292534152 · doi:10.21203/rs.3.rs-1859594/v1

Physiotherapy intervention on changes in post-chemotherapy sensibility with taxanes

2022· preprint· en· W4292534152 on OpenAlexaboutno aff
Maria Thais Rodrigues, Roberta Pitta Costa Luz, Carmen S. Alliz, Thais Andreotti Gelsi Reis, Samantha Karlla Lopes de Almeida Rizzi, Afonso Nazário, Simone Elias, Gil Facina

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldMedicine
TopicCancer Treatment and Pharmacology
Canadian institutionsnot available
Fundersnot available
KeywordsTaxaneSensibilityMedicineChemotherapyPhysical therapyInternal medicineBreast cancerCancer

Abstract

fetched live from OpenAlex

Abstract OBJECTIVE: Evaluate the presence of changes in post-chemotherapy sensibility with Taxane and the efficiency of a physiotherapy intervention that aims at the improvement of this condition. METHODS: We conducted an uncontrolled, longitudinal quantitative and prospective study on 23 patients. Four were not included in the study for not showing changes in sensibility or having a skin condition that rendered the evaluation impossible. The patients responded to the McGill and FACT G-Taxane questionnaires after the sensibility evaluation with a Semmes-Weinstein esthesiometer, an intervention session using a Peridell® therapeutic massager and a subsequent sensibility revaluation. RESULTS: Two regions with the best responses to the intervention were the dermatomes L5 and S1, with initial means of 5.33 and 5.53 and final means of 5.64 and 5.78, respectively (p = 0.012 e 0.020). The general analysis for both superior and inferior limbs showed an increase in the means, with an initial mean of 5.69 and a final mean of 5.81 (p = <0.001). There was a negative correlation between FACT G-Taxane and the McGill Questionnaire (-0.738 e p = <0.001). CONCLUSION: Vibratory stimulus of Peridell® therapeutic massager showed a significant improvement of changes in sensibility on the region of the dermatomes L5 and S1, especially on milder changes. The correlation between FACT G-Taxane and the McGill questionnaire suggests that the more pain the patient feels, there is less life quality and there are more symptoms of toxicity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.071
GPT teacher head0.494
Teacher spread0.423 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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