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Record W4292812913

Maple syrup-derived polyphenolics potentiate antibiotics in vivo

2019· preprint· en· W4292812913 on OpenAlexaff
Nathalie Tufenkji, Vimal B. Maisuria, Dao Nguyen, Éric Déziel, Pierre-André Casgrain

Bibliographic record

VenueHAL (Le Centre pour la Communication Scientifique Directe) · 2019
Typepreprint
Languageen
FieldChemistry
TopicPlant-Derived Bioactive Compounds
Canadian institutionsArmand Frappier MuseumMcGill University
Fundersnot available
KeywordsPolyphenolMapleChemistryIn vivoAntibioticsFood scienceBotanyBiochemistryBiologyBiotechnologyAntioxidant
DOInot available

Abstract

fetched live from OpenAlex

Antibiotic resistance is a rapidly growing threat to global public health. This study looked at the potential of a polyphenolic rich extract from maple syrup (PRMSE) to potentiate the effects of common antibiotics in vivo, which could lessen the need for antibiotic usage. Results indicated that PRMSE and ciprofloxacin combination therapy displayed synergy against P. aeruginosa in and murine infection models at clinically relevant doses, suggesting that PRMSE may have potential as an antibiotic adjuvant for the treatment of different types of bacterial infections

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.221
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

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