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Record W4292812913

Maple syrup-derived polyphenolics potentiate antibiotics in vivo

2019· preprint· en· W4292812913 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueHAL (Le Centre pour la Communication Scientifique Directe) · 2019
Typepreprint
Languageen
FieldChemistry
TopicPlant-Derived Bioactive Compounds
Canadian institutionsArmand Frappier MuseumMcGill University
Fundersnot available
KeywordsPolyphenolMapleChemistryIn vivoAntibioticsFood scienceBotanyBiochemistryBiologyBiotechnologyAntioxidant
DOInot available

Abstract

fetched live from OpenAlex

<p>Antibiotic resistance is a rapidly growing threat to global public health. This study looked at the potential of a polyphenolic rich extract from maple syrup (PRMSE) to potentiate the effects of common antibiotics in vivo, which could lessen the need for antibiotic usage. Results indicated that PRMSE and ciprofloxacin combination therapy displayed synergy against P. aeruginosa in and murine infection models at clinically relevant doses, suggesting that PRMSE may have potential as an antibiotic adjuvant for the treatment of different types of bacterial infections</p>

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.147
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0020.003
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.221
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it