Reply: Right, wrong, or somewhere in between?
Bibliographic record
Abstract
R.C.A. has an unrestricted grant from Pfizer Canada Inc and has received honoraria from Abbott Nutrition, Edwards Lifesciences, and AVIR Pharmaceuticals for work unrelated to this manuscript. All other authors reported no conflicts of interest.The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.Grunfeld and colleagues1Grunfeld M. Kai M. Ohira S. Mechanism of stroke in the setting of postcardiotomy veno-arterial extracorporeal membrane oxygenation support.J Thorac Cardiovasc Surg Open. April 12, 2022; ([Epub ahead of print])Google Scholar provide interesting insight on a potential mechanism for observed increases in right-sided stroke that were recently reported during right axillary venoarterial extracorporeal membrane oxygenation (ECMO).2Schaefer A.-K. Distelmaier K. Riebandt J. Goliasch G. Bernardi M.H. Zimpfer D. et al.Access site complications of postcardiotomy extracorporeal life support.J Thorac Cardiovasc Surg. November 25, 2021; ([Epub ahead of print])Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar In addition to embolization, they suggest that mixing between ECMO flow and the native cardiac output may produce an environment predisposing to right-sided stroke, including through blood stasis and leading to innominate artery thrombosis, supported by compelling clinical images.Differential oxygenation (ie, “North-South” or “Harlequin” syndrome) is a well-known potential downside of peripheral venoarterial ECMO,3Lorusso R. Whitman G. Milojevic M. Raffa G. McMullan D.M. Boeken U. et al.2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients.Eur J Cardiothorac Surg. 2021; 59: 12-53Crossref PubMed Scopus (20) Google Scholar wherein the native cardiac output competes with retrograde ECMO flow and differentially perfuses the right brachiocephalic and carotid arteries with deoxygenated blood. Although we have not experienced this complication as vividly as described by Grunfeld and colleagues, the analogous mechanism is certainly a plausible explanation for the observed findings after axillary cannulation and one for which all peripherally cannulated patients must be closely monitored.Notably, this complication may be obviated by using central cannulation. One approach that we have taken in carefully selected patients is that of closed-chest central ECMO cannulation. In this approach, a standard aortic arch cannula is tunneled through the right second intercostal space into the ascending aorta while a 2-stage venous cannula is tunneled through the abdominal fascia and into the right atrium with the tip positioned in the inferior vena cava. If desired, an apical left ventricular vent can be inserted with the assistance of a long angiocatheter and modified Seldinger technique for dilation of the apex and a left inframammary incision. Standard sternotomy closure may then be performed. This provides the early chest closure benefits of peripheral cannulation, including careful patient mobilization, although hemostasis must be particularly meticulous, given the need for systemic heparinization. R.C.A. has an unrestricted grant from Pfizer Canada Inc and has received honoraria from Abbott Nutrition, Edwards Lifesciences, and AVIR Pharmaceuticals for work unrelated to this manuscript. All other authors reported no conflicts of interest.The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. R.C.A. has an unrestricted grant from Pfizer Canada Inc and has received honoraria from Abbott Nutrition, Edwards Lifesciences, and AVIR Pharmaceuticals for work unrelated to this manuscript. All other authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. Grunfeld and colleagues1Grunfeld M. Kai M. Ohira S. Mechanism of stroke in the setting of postcardiotomy veno-arterial extracorporeal membrane oxygenation support.J Thorac Cardiovasc Surg Open. April 12, 2022; ([Epub ahead of print])Google Scholar provide interesting insight on a potential mechanism for observed increases in right-sided stroke that were recently reported during right axillary venoarterial extracorporeal membrane oxygenation (ECMO).2Schaefer A.-K. Distelmaier K. Riebandt J. Goliasch G. Bernardi M.H. Zimpfer D. et al.Access site complications of postcardiotomy extracorporeal life support.J Thorac Cardiovasc Surg. November 25, 2021; ([Epub ahead of print])Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar In addition to embolization, they suggest that mixing between ECMO flow and the native cardiac output may produce an environment predisposing to right-sided stroke, including through blood stasis and leading to innominate artery thrombosis, supported by compelling clinical images. Differential oxygenation (ie, “North-South” or “Harlequin” syndrome) is a well-known potential downside of peripheral venoarterial ECMO,3Lorusso R. Whitman G. Milojevic M. Raffa G. McMullan D.M. Boeken U. et al.2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients.Eur J Cardiothorac Surg. 2021; 59: 12-53Crossref PubMed Scopus (20) Google Scholar wherein the native cardiac output competes with retrograde ECMO flow and differentially perfuses the right brachiocephalic and carotid arteries with deoxygenated blood. Although we have not experienced this complication as vividly as described by Grunfeld and colleagues, the analogous mechanism is certainly a plausible explanation for the observed findings after axillary cannulation and one for which all peripherally cannulated patients must be closely monitored. Notably, this complication may be obviated by using central cannulation. One approach that we have taken in carefully selected patients is that of closed-chest central ECMO cannulation. In this approach, a standard aortic arch cannula is tunneled through the right second intercostal space into the ascending aorta while a 2-stage venous cannula is tunneled through the abdominal fascia and into the right atrium with the tip positioned in the inferior vena cava. If desired, an apical left ventricular vent can be inserted with the assistance of a long angiocatheter and modified Seldinger technique for dilation of the apex and a left inframammary incision. Standard sternotomy closure may then be performed. This provides the early chest closure benefits of peripheral cannulation, including careful patient mobilization, although hemostasis must be particularly meticulous, given the need for systemic heparinization. Mechanism of stroke in the setting of postcardiotomy venoarterial extracorporeal membrane oxygenation supportJTCVS OpenVol. 11PreviewWith great interest we read the study by Schaefer and colleauges,1 who conducted a detailed analysis of the outcomes of postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) support focusing on stroke and cannulation-related complications. The stroke rate of right axillary (RAX) VA-ECMO was greater than that of femoral cannulation. In both axillary and femoral VA-ECMO, the right hemisphere was the most common stroke location (64.5% in RAX and 50% in femoral). This stroke laterality trend in RAX cannulation was similar in our experiences. Full-Text PDF Open Access
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.014 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".