Role of the Tie2 agonist Vasculotide in murine Staphylococcus aureus pneumonia
Bibliographic record
Abstract
Introduction Community acquired pneumonia (CAP) is a significant cause of mortality worldwide. Despite adequate antibiotic treatment, severe pneumonia may induce pulmonary endothelial inflammation and hyperpermeability, resulting in life threatening lung failure. Compared to Streptococcus pneumoniae Staphylococcus aureus (S.a.) is a less common pathogen in CAP, but associated with a severe course of disease and a high mortality rate. Angiopoietin-1 (Ang-1) mediated Tie2-receptor activation reduces inflammation and stabilizes lung endothelial barrier. We have recently shown that the PEGylated (polyethylene glycol) Ang-1 mimic Vasculotide (VT) reduces lung hyperpermeability in murine pneumococcal pneumonia. The aim of our study was to investigate the influence of VT in an in vivo model of S.a. infected mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".