Editorial: Mechanisms of hox-driven patterning and morphogenesis
Bibliographic record
Abstract
Editorial on the Research Topic Mechanisms of hox-driven patterning and morphogenesisThe Hox genes have attracted the interest of scientist for decades.Their organization in genetic clusters, their ordered chromosomal alignment and the correlation of this disposition with the evolutionary conserved gene expression along the anteroposterior axis have excited the curiosity of researchers and prompted countless investigations.Hox proteins have also been studied as examples of transcription factors that activate particular genes at certain positions.The present Research Topic Mechanisms of Hox-Driven Patterning and Morphogenesis gathers a series of reviews and original articles on Hox expression and function in different model organisms.The seminal work of Ed Lewis characterized transformations in the Drosophila cuticle due to mutations in Bithorax Complex (BX-C) genes.Subsequent studies revealed that Hox genes are expressed and required also in muscles or nervous system.Two reviews focus on the role of Hox genes in these tissues.The manuscript by Poliacikova et al. reviews the role of Hox genes in the different steps of muscle specification in Drosophila and vertebrates.The authors describe Hox activity in somatic/skeletal, cardiac and visceral muscle development, explain the cooperation of Hox proteins with muscle-specific proteins and explain the role of these genes in neuromuscular circuits.These neuromuscular networks are detailed in the work of Joshi et al.They report musclemotoneuron circuits in Drosophila and how these impact on development and behavior.The authors first summarize Hox role in specification of the central nervous system and then review recent advances in Hox determination of motoneuron morphology and physiology, focusing in two larval behaviors, locomotion and feeding, and two adult ones, egg-laying and self-righting.Although it is well established that Hox genes are required during development, recent studies have uncovered a Hox function in adults, as described in the above review.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.010 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.009 | 0.013 |
| Insufficient payload (model declined to judge) | 0.018 | 0.017 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".