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Record W4294677238 · doi:10.1016/s2213-2600(22)00260-0

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

2022· article· en· W4294677238 on OpenAlexaff
Joshua J. Solomon, Sonye K. Danoff, Felix Woodhead, Shelley Hurwitz, Rie Maurer, Ian Glaspole, Paul F. Dellaripa, Bibek Gooptu, Robert Vassallo, Gerard Cox, Kevin R. Flaherty, Huzaifa Adamali, Michael Gibbons, Lauren Troy, Ian Forrest, Joseph A. Lasky, Lisa Spencer, Jeffrey A. Golden, Mary Beth Scholand, Nazia Chaudhuri, Mark A. Perrella, David A. Lynch, Daniel C. Chambers, Martin Kolb, Cathie Spino, Ganesh Raghu, Hilary J. Goldberg, Iván O. Rosas, Shana Haynes-Harp, F. Poli, Coimbatore Sree Vidya, Rebecca R. Baron, Timothy Clouser, Tracy J. Doyle, Anthony H. Maeda, Kristin B. Highland, Jemima F. Albayda, Sarah E. Collins, Karthik Suresh, John M. Davis, Andrew H. Limper, Isabel Amigues, Kristina Eliopoulos, Stephen M. Humphries, John Huntwork, Chris Glynn, Steve Duncan, Maria I. Danila, Marilyn K. Glassberg, Elana M. Oberstein, Elizabeth A. Belloli, Linda Briggs, Vivek Nagaraja, Linda Cholewa, Donna DiFranco, Edward Green, Christie Liffick, Tanvi Naik, Genevieve Montas, Dorota Lebiedz‐Odrobina, Reba Bissell, Mark H. Wener, Lisa Lancaster, Leslie J. Crawford, Karmela K Chan, Robert J. Kaner, Alicia Morris, Xiaoping Wu, Nader Khalidi, Christopher J. Ryerson, Alyson W. Wong, Charlene D. Fell, Sharon LeClercq, Mark Hyman, Shane Shapera, Shikha Mittoo, Shireen Shaffu, Karl Gaffney, Andrew M. Wilson, Shaney Barratt, Harsha Gunawardena, Rachel K. Hoyles, Joel David, Namrata Kewalramani, Toby M. Maher, Philip L. Molyneaux, Maria Kokosi, Matthew Cates, Abdul Ashish, Gladstone Chelliah, Helen Parfrey, Muhunthan Thillai, Josephine Vila, Sophie Fletcher, Paul Beirne, C Favager, Jo Brown, Julie Dawson, Pilar Rivera‐Ortega, Sahena Haque, Pippa Watson, Jun Keng Khoo, Karen Symons, Peter Youssef, John A. Mackintosh

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2022
Typearticle
Languageen
FieldMedicine
TopicInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Canadian institutionsMcMaster University
FundersGenentech
KeywordsMedicineTolerabilityRheumatoid arthritisPlaceboPirfenidoneInterstitial lung diseaseInternal medicineDouble blindArthritisAdverse effectLungIdiopathic pulmonary fibrosisAlternative medicinePathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0010.000
Science and technology studies0.0010.002
Scholarly communication0.0010.002
Open science0.0010.000
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.300
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations208
Published2022
Admission routes1
Has abstractno

Explore more

Same venueThe Lancet Respiratory MedicineSame topicInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisFrench-language works237,207