Synthesis and characterization of novel conformers of ( <i>E</i> ) <i>‐</i> 2‐(3‐nitro‐ <i>H</i> ‐imidazo[1,2‐ <i>a</i> ]pyridin‐2‐ylthio)‐ <i>N</i> ′‐benzylideneacetohydrazide derivatives
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Eighteen new N ‐acylhydrazones ( 9a–r ) containing the imidazo[1,2‐ a ]pyridine scaffold were synthesized through a seven steps reaction sequence, ending with a condensation of 2‐(3‐nitro‐ H ‐imidazo[1,2‐ a ]pyridin‐2‐ylthio)acetohydrazide with various benzaldehyde derivatives ( 8a–r ). All synthesized compounds were characterized by 1D NMR ( 1 H and 13 C NMR) and 2D NMR (NOESY) spectroscopic analyses and high‐resolution mass spectrometry (HRMS). The analysis of 1 H NMR data performed at room temperature in deuterated dimethylsulfoxide (DMSO‐ d 6 ) revealed the presence of ( E ) ‐ 2‐(3‐nitro‐ H ‐imidazo[1,2‐ a ]pyridin‐2‐ylthio)‐ N ′‐benzylideneacetohydrazide ( 9a–r ) as a mixture of two conformers, namely, syn‐periplanar E ( sp E ) and anti‐periplanar E ( ap E ). For all N ‐acylhydrazones that were synthesized, the sp E conformer was found to be the major form except in the case of hydrazone derived from o ‐hydroxybenzaldehyde.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it