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Record W4296015220 · doi:10.1016/j.matbio.2022.09.001

Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation

2022· article· en· W4296015220 on OpenAlexfundno aff
Sinan Lin, Alessandro Musso, Jie Wang, Pranab K. Mukherjee, Gail West, Ren Mao, Ruishen Lyu, Jiannan Li, Shuai Zhao, Michael Elias, Yael Haberman, Lee A. Denson, Subra Kugathasan, Minhu Chen, Doug Czarnecki, Dina Dejanovic, Hongnga T. Le, Jyotsna Chandra, Jeremy M. Lipman, Scott R. Steele, Quang Tam Nguyen, Claudio Fiocchi, Florian Rieder

Bibliographic record

VenueMatrix Biology · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsnot available
FundersChildren's Hospital of PittsburghUniversity of North Carolina at Chapel HillIWK Health CentreHospital for Sick ChildrenCrohn's and Colitis FoundationTexas Children's HospitalUniversity of OttawaCedars-Sinai Medical CenterUniversity of Texas Southwestern Medical CenterNational Institute of Diabetes and Digestive and Kidney DiseasesJohns Hopkins UniversityUniversity of TorontoCleveland ClinicChildren's Hospital of PhiladelphiaLeona M. and Harry B. Helmsley Charitable TrustNational Natural Science Foundation of ChinaNationwide Children's HospitalUniversity at BuffaloNational Science Foundation
KeywordsExtracellular matrixIntegrinDecellularizationTumor necrosis factor alphaInflammationCell biologyImmunologyCell adhesion moleculeCell adhesionInflammatory bowel diseaseImmune systemMyofibroblastCancer researchChemistryMedicineCellBiologyPathologyFibrosisDiseaseBiochemistry

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.266
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations33
Published2022
Admission routes1
Has abstractno

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