Synthesis and dissolution behaviour of nateglinide‐nicotinamide cocrystals by simple slurry crystallization
Bibliographic record
Abstract
Abstract Pharmaceutical cocrystals have received increasing attention in improving drug physicochemical properties. Here, we successfully synthesized a cocrystal of nateglinide (a non‐sulphonylurea hypoglycemic agent) and nicotinamide by slurry crystallization. The cocrystal formation was confirmed by powder X‐ray diffraction, differential scanning calorimetry, and Fourier‐transform infrared spectroscopy. The density functional theory calculation at the theoretical level of B3LYP/6–31 + G ( d , p ) revealed that the hydrogen bonding site of the cocrystal was formed between the carboxyl group of nateglinide and the amide bond of nicotinamide. Moreover, the cocrystal showed improved dissolution capacity in 3 pH buffers, which provides an opportunity for rapid absorption of the active ingredient.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".