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Record W4296105368 · doi:10.3389/fmolb.2022.1012485

Editorial: Glycotherapeutics: Design, synthesis, function and biomedical application of agents emerging from glycochemistry and glycobiology

2022· editorial· en· W4296105368 on OpenAlexafffund
M. Osman Sheikh, Chantelle J. Capicciotti, Stéphanie Olivier‐Van Stichelen

Bibliographic record

VenueFrontiers in Molecular Biosciences · 2022
Typeeditorial
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGlycosylation and Glycoproteins Research
Canadian institutionsQueen's University
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Child Health and Human DevelopmentNatural Sciences and Engineering Research Council of CanadaMedical College of Wisconsin
KeywordsGlycobiologyFunction (biology)Computational biologyComputer scienceNanotechnologyBiochemical engineeringData scienceBiologyEngineeringGlycanBiochemistryMaterials scienceCell biology

Abstract

fetched live from OpenAlex

Glycotherapeutics: Design, synthesis, function and biomedical application of agents emerging from glycochemistry and glycobiology Post-translational glycosylation is a non-template driven process for the addition of carbohydrates, or glycans, to biomolecules such as protein and lipids. It is well recognized that glycosylation impacts many cellular processes including, but not limited to, protein folding, trafficking, receptor binding, signaling, inflammation, and cell-to-cell/matrix adhesion (Varki 2017). Additionally, glycans can be used in the targeting of drugs in diseases such as cancer

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.479
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.265
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes2
Has abstractyes

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