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Record W4297235444 · doi:10.1038/s41431-022-01194-8

Genetic discrimination still casts a large shadow in 2022

2022· article· en· W4297235444 on OpenAlexafffund
Yann Joly, Gratien Dalpé

Bibliographic record

VenueEuropean Journal of Human Genetics · 2022
Typearticle
Languageen
FieldEngineering
TopicBiomedical and Engineering Education
Canadian institutionsMcGill UniversityMcGill Genome Centre
FundersCIHR Skin Research Training CentreCanadian Institutes of Health ResearchGovernment of CanadaGenome Canada
KeywordsShadow (psychology)GeneticsEvolutionary biologyBiologyComputational biologyPsychology

Abstract

fetched live from OpenAlex

Genetic discrimination (GD) is not new. It is usually understood as a type of discrimination based on genetic characteristics that is intended to infringe or has the effect of infringing on human rights, fundamental freedoms, and human dignity [ 1 ]. Like sexual, ethnic, or disability-based discrimination, GD can be a source of exclusion. It may limit a person’s social and professional opportunities and lead to psychological, social, and economic disadvantage and distress [ 2 ]. The first cases of GD surfaced in the fields of personal insurance and employment in the United States in the late 1970s. Since then, many countries in America, Europe, Asia, and Oceania have adopted laws to prevent this kind of discrimination. In low- and middle-income countries with less capacity to perform genetic tests on a broad scale and facing pressing health and economic challenges, non-GD laws are rarely a priority [ 3 ].

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.011
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.038
Threshold uncertainty score0.126

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.011
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0040.008
Scholarly communication0.0050.006
Open science0.0010.004
Research integrity0.0100.011
Insufficient payload (model declined to judge)0.0380.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.220
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations37
Published2022
Admission routes2
Has abstractyes

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