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Record W4297926186 · doi:10.17615/6az3-p679

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

2020· article· en· W4297926186 on OpenAlexfundno aff
Brian E. Henderson, Emily White, Kana Wu, Edward L. Giovannucci, Robert E. Schoen, Steven Gallinger, Jean Wactawski‐Wende, Tabitha A. Harrison, Martha L. Slattery, Mathieu Lemire, Jo Ann E. Manson, Sonja I. Berndt, David V. Conti, Graham Casey, Bette J. Caan, Linda T. Hiraki, Fredrick R. Schumacher, Kimmie Ng, Polly A. Newcomb, John L. Hopper, Jenny Chang‐Claude, Jing Ma, Hermann Brenner, Michael Hoffmeister, Andrew T. Chan, Brent W. Zanke, Stephen J. Chanock, Thomas J. Hudson, Sébastien Küry, John A. Baron, Stéphane Bezieau, John D. Potter, Mark A. Jenkins, Aditi Hazra, Conghui Qu, Hongmei Nan, Daniela Seminara, Loı̈c Le Marchand, Carolyn M. Hutter, David Duggan, Charles S. Fuchs, Richard B. Hayes, Peter Kraft

Bibliographic record

VenueUNC Libraries · 2020
Typearticle
Languageen
FieldMedicine
TopicVitamin D Research Studies
Canadian institutionsnot available
FundersNational Cancer InstituteNational Heart, Lung, and Blood InstituteOntario Ministry of Research and InnovationCanadian Institutes of Health ResearchGroupement des Entreprises Françaises dans la lutte contre le CancerAssociation Anne de Bretagne GenetiqueBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftConseil Régional des Pays de la LoireCanadian Cancer Society Research InstituteU.S. Department of Health and Human ServicesNational Institutes of HealthOffice of Dietary SupplementsJohns Hopkins UniversityDivision of Cancer Prevention, National Cancer InstituteMinisterio de Economía y Competitividad
KeywordsColorectal cancerCancerMedicineInternal medicineOncologyVitamin D and neurology

Abstract

fetched live from OpenAlex

Experimental evidence has demonstrated an anti-neoplastic role for vitamin D in the colon and higher circulating 25-hydroxyvitamin D (25[OH]D) levels are consistently associated with a lower risk of colorectal cancer (CRC). Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified SNPs from four gene regions, collectively explain approximately 5% of the variance in circulating 25(OH)D.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.019
Threshold uncertainty score0.341

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.253
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

Explore more

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