Caractérisation de l'expression et de la fonction du facteur de transcription Nrf3 dans les cellules humaines
Bibliographic record
Abstract
En collaboration avec V. Blank (Université McGill, Montréal), nous avons montré que le facteur de transcription Nrf3 est fortement exprimé, au niveau ARN et protéine, dans les cellules du placenta humain et les lignées de choriocarcinomes. De plus l'expression de Nrf3 est stimulée par le TNF-α dans les lignées de choriocarcinome et d'autres lignées tumorales humaines. Au niveau fonctionnel, nous avons montré par retard de migration électrophorétique que Nrf3 peut s'associer à toutes les petites protéines Maf connues (MafF, MafG, MafK) pour se lier à l'ADN. Après avoir cloné le promoteur de NRF3, nous avons recherché un rôle de Nrf3 par une approche d'interférence d'ARN dans plusieurs modèles de lignées tumorales humaines.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".