The biochemical genetics of rudimentary mutants of Drosophila melanogaster
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Bibliographic record
Abstract
Aspartate carbamoyltransferase (ACT) levels were determined in larvae from two completely complementing and one non-complementing rudimentary strain, as well as in wild-type larvae. The levels were low in the non-complementing and in one of the complementing strains, whereas the other complementing strain had wild-type levels. When viewed together with the previous findings of a nutritional requirement for pyrimidines in the non-complementing strain, that can be satisfied by carbamoyl aspartate, these results indicate that the rudimentary locus determines the first two enzyme activities in the pyrimidine biosynthetic pathway; carbamoyl phosphate synthetase and aspartate carbamoyltransferase. Addition of uracil to the culture medium caused no decrease in the level of ACT in wild type or ACT-positive rudimentary larvae indicating that end product repression of this enzyme does not take place in Drosophila.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it