Ontogeny of Responses of Rabbit Aorta to Atrial NatriureticFactor and Isoproterenol
Bibliographic record
Abstract
Ontogeny of the vasorelaxant effects of atrial natriuretic factor (ANF) and isoprénaline and of the vasoconstrictor effects of potassium and phenylephrine were studied on aortic strips from rabbits aged 1, 2, 3, 6, 10 and 32-48 (adult) weeks. ANF caused complete relaxation of phenylephrine- and potassium-contracted aortic strips from all age groups of rabbits and its potency was not altered by age and by the agent used to cause contractions. On the other hand, the vasorelaxant efficacy and potency of isoproterenol decreased with age. Also, isoprenaline was less potent and efficacious on aortic strips contracted with potassium than on strips contracted with phenylephrine. The sensitivity of aorta to phenylephrine increased after 2 weeks of age, but that to potassium remained the same at all ages. In conclusion, our data indicate that the vasorelaxant effects of ANF and the vasoconstrictor effects of potassium on rabbit aorta are not altered by age whereas the sensitivity of the vascular smooth muscle to isoproterenol decreases and that to phenylephrine increases with maturation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".