Patent Ductus Arteriosus (PDA) and Response to Late Surfactant Treatment in Premature InfantsRunning Title: Ductus Arteriosus and Late Surfactant Treatment
Bibliographic record
Abstract
Abstract Objective To determine clinical/echocardiography (ECHO) phenotype of response to late surfactant, according to patent ductus arteriosus (PDA) status. Study Design Infants ≤26 +6 weeks gestational age (GA), who received ≥1 surfactant dose after postnatal day 6 with known PDA status, were enrolled. Response to surfactant, based on change in respiratory severity score, and relationship with PDA status were evaluated via univariate analysis. Results In total, 35 patients were enrolled (total of 71 doses of surfactant), whose mean weight and GA at birth were 595g(508, 696) and 23.3(22.7, 25) weeks. Positive response to late surfactant was independently associated with absence of PDA [OR 26(2, 334), p=0.01] whereas presence of PDA was associated with negative response [OR 12(1.1, 126), p=0.04]. Conclusions In neonates ≤26+6 weeks gestation response to late surfactant is influenced by PDA status. Future trials should consider PDA status when refining patient selection for late surfactant treatment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".