Investigation on stereoconfiguration of azoxybenzene formed via Grignard reaction and further Consequences on Z & E isomerism of diazeniumdiolates
Bibliographic record
Abstract

 
 
 
 Nitric oxide’s importance in biochemistry was recognized in the mid 1980’s. Nitric oxide (NO) is critical for the function of neuronal cells, for blood flow and to defend against tumour cells and microorganisms. Diazeniumdiolates, ions of structure [RN(O)NO]-, are being used as probes to study the biological and pharmacological implications of NO because compounds bearing this functional group have been found to release NO. The conformation about the N=N double bond of diazeniumdiolates has been shown through crystallographic studies to be predominantly Z. To study the stereospecificity of diazeniumdiolates, azoxybenzene was synthesized via a “forgotten” synthetic pathway pioneered by Stevens in 1963 which involved a reaction between an organonitrosohydroxylamine tosylate, RN(O)NOTs, and a Grignard reagent. The product from this preparation was directly compared to azoxybenzene made from a coupling reaction.
 
 
 
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".