SSI 2016 43rd Scandinavian Society for Immunology Meeting Turku, Finland 10–13 May 2016
Bibliographic record
Abstract
Introduction: We have previously identified and characterized fibrinogen C domain-containing 1 (FIBCD1) as a homotetrameric type II transmembrane protein. FIBCD1 is a member of the fibrinogen- related protein (FReP) family, and is thought to play a crucial role in the innate immune system (Schlosser et al, 2009; Thomsen et al, 2011).<br/>FIBCD1 functions as an endocytic receptor, binding chitin and other acetylated compounds with high affinity. We hypothesize that FIBCD1 serves as a pattern recognition molecule for acetylated compounds, found in various pathogens such as helminths and fungi. We have previously shown that FIBCD1 is present at mucosal surfaces in the lung and large intestine.<br/>Aim: The present study investigates the distribution and localization of FIBCD1 in various healthy human tissues.<br/>Results: We used a monoclonal antibody directed towards the FIBCD1 ectodomain in an immunohistochemistry-based analysis and demonstrate that FIBCD1 protein is highly expressed at the apical surfaces of the epithelium throughout the gastrointestinal tract, in the uterus, testis, bladder, gallbladder and the salivary glands. To a lesser extent, FIBCD1 is expressed in the pancreas, the spleen and the tonsils.<br/>Moreover, using quantitative real-time PCR we demonstrate that FIBCD1 mRNA is highly expressed in the gastrointestinal tract, the lung, the adrenal gland and the testis, which is in coherence with our immunohistochemical findings.<br/>Conclusion: FIBCD1 is present at the apical epithelial surfaces of various mucosal tissues. This strengthens our hypothesis that FIBCD1 is a novel player involved in the innate immune responses of the mucosa.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".