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Record W4303491825 · doi:10.1101/2022.10.07.511250

BioDiscViz : a visualization support and consensus signature selector for BioDiscML results

2022· preprint· en· W4303491825 on OpenAlexaff
Sophiane Bouirdene, Mickaël Leclercq, Léopold Quitté, Steve Bilodeau, Arnaud Droit

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2022
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene expression and cancer classification
Canadian institutionsUniversité Laval
Fundersnot available
KeywordsOverfittingComputer scienceBootstrapping (finance)VisualizationMachine learningFlexibility (engineering)Field (mathematics)Artificial intelligenceData miningData scienceArtificial neural networkStatistics

Abstract

fetched live from OpenAlex

Abstract Machine learning (ML) algorithms are powerful tools to find complex patterns and biomarker signatures where conventional statistical methods may fail to identify them. While the ML field made significant progress, state of the art methodologies to build efficient and non-overfitting models are not always applied in the litterature. To this purpose, automatic programs, such as BioDiscML, have been designed to identify biomarker signatures and correlated features while escaping overfitting using multiple evaluation strategies, such as cross validation, bootstrapping and repeated holdout. To further improve BioDiscML and reach a broader audience, better visualization support and flexibility in choosing the best models and signatures are needed. Thus, to provide researchers with an easily accessible and usable tool for in depth investigation of the results from BioDiscML outputs, we developed a visual interaction tool called BioDiscViz. This tool provides summaries, tables and graphics, in the form of Principal Component Analysis (PCA) plots, heatmaps and boxplots for the best model and the correlated features. Furthermore, this tool also provides visual support to extract a consensus signature from BioDiscML models using a combination of filters. BioDiscViz will be a great visual support for research implying machine learning, hence new opportunities in this field by opening it to a broader community.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.070
Threshold uncertainty score0.233

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.018
Meta-epidemiology (narrow)0.0040.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0070.003
Science and technology studies0.0010.001
Scholarly communication0.0050.004
Open science0.0040.005
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0700.018

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.257
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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