Bibliographic record
Abstract
No AccessJournal of UrologyAdult Urology1 Dec 2022Editorial CommentThis article comments on the following:Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level Braden Millan and Jehonathan H. Pinthus Braden MillanBraden Millan Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada More articles by this author and Jehonathan H. PinthusJehonathan H. Pinthus *Email: E-mail Address: [email protected] Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002923.01AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 208(6), pp. 1224–1225 References 1. Extragonadal steroids contribute significantly to androgen receptor activity and development of castration resistance in recurrent prostate cancer after primary therapy. J Urol. 2020; 203(5):940-948. Link, Google Scholar 2. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res. 2011; 71(20):6503-6513. Google Scholar 3. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004; 10(1):33-39. Google Scholar © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsRelated articlesJournal of Urology14 Sep 2022Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level Volume 208Issue 6December 2022Page: 1224-1225 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Braden Millan Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada More articles by this author Jehonathan H. Pinthus Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada *Email: E-mail Address: [email protected] More articles by this author Expand All Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.040 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.006 | 0.004 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.011 | 0.008 |
| Insufficient payload (model declined to judge) | 0.441 | 0.269 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".