Bibliographic record
Abstract
Editorial on the Research Topic Sirtuins and brain homeostasisThe homeostatic functions of the human brain include but are not limited to maintaining daily physiological cycles, such as the sleep-wake cycle, controlling appetiteand thirst, regulating energy and glucose metabolism, regulating body temperature and blood pressure, controlling the production and release of hormones, and regulating cognitive processes (Grigorenko et al., 2016;Roh et al., 2016;González-García et al., 2021).Therefore, the preservation of brain homeostasisis crucial for maintaining the state of steady internal, physical, and chemical conditions of a whole organism (Graceli et al., 2020).Epigenetic mechanisms that control gene expression/ activity without changing the DNA sequence play an important role in brain homeostasis.These mechanisms include DNA methylation, histone modifications, nucleosome repositioning, higher-order chromatin remodeling, noncoding RNAs, and RNA and DNA editing (Mehler, 2008;Mansuy and Mohanna, 2011;Petralla et al., 2021).Sirtuins comprise a family of evolutionarily conserved enzymes that perform NAD + -dependent protein deacetylation/acetylation and are involved in the epigenetic machinery (Bosch-Presegué and Vaquero, 2015;Kosciuk et al., 2019).In mammals, seven isoforms of sirtuins (SIRT1-SIRT7) have been identified in different cellular compartments (i.e., nucleus, mitochondria, cytosol), and knowledge about their comprehensive operation is rapidly expanding (Grabowska et al., 2017;Avilkina et al., 2022).This special issue, consisting of original and review papers, has been prepared to showcase thelatest information about the role of sirtuins in the preservation of brain homeostasis in neurological disorders, including neurodegenerative diseases and stroke, and in the context of behavioral responsiveness.A literature review clearly shows that sirtuins regulate various cell functions in the central nervous system (CNS) (Yan et al.).In the mature CNS, this applies to both neurons and glial cells (i.e., astrocytes, oligodendrocytes, and microglial cells).Abnormal levels of sirtuins coexist with CNS disorders, resulting in clinically relevant progressive cognitive impairment and dysfunction of social and physical abilities.Thus, as epigenetic factors, sirtuins participate in processes such as oxidative stress, cell mitigation, apoptosis, and mitochondrial biogenesis, and altered sirtuin
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.011 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.011 | 0.013 |
| Insufficient payload (model declined to judge) | 0.021 | 0.016 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".