17β‐hydroxysteroid dehydrogenase type 2 activity, expression and cellular localization in abdominal adipose tissues from women
Bibliographic record
Abstract
Abstract Context : 17β‐hydroxysteroid dehydrogenase type 2 (17β‐HSD2) may be involved in the local modulation of estradiol (E2) availability in adipose tissues. Objective: To assess the conversion of E2 into estrone (E1) as well as the expression of 17β‐HSD2 and its localization in omental (OM) and subcutaneous (SC) adipose tissues obtained from women. Methods: Rates of 14 C‐E1 formation from 14 C‐E2 were measured in OM and SC adipose tissue homogenates from 29 women. Specific 17β‐HSD2 inhibitor EM‐919 was tested in OM and SC adipose tissue homogenates ( n = 6). 17β‐HSD2 mRNA expression was measured in whole OM and SC adipose tissues ( n = 14). Cellular localization of the enzyme was examined using immunohistochemistry. Anthropometric measurements were obtained and body composition as well as body fat distribution were measured. Results: Significant 14 C‐E1 formation from 14 C‐E2 in OM and SC tissue homogenates was detected. The rate of 14 C‐E1 formation was significantly higher in OM than SC adipose tissue ( p < .0001). The conversion of 14 C‐E2 to 14 C‐E1 was significantly inhibited by EM‐919 in OM ( p < .05) and SC ( p < .05) adipose tissues. Significantly higher expression of 17β‐HSD2 mRNA in OM versus SC fat was found ( p = .03). 17β‐HSD2 was localized in the vasculature of OM and SC tissues. Significant negative associations were detected between OM 17β‐HSD2 activity and body mass index, WC, lean body mass as well as SC adipose tissue areas. Conclusion: 17β‐HSD2 converts E2 to E1 in OM and SC adipose tissues of women. The activity of this enzyme decreases with increasing adiposity.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".