57 Update of IMPACT Invasive Meningococcal Surveillance, 2016-2020
Bibliographic record
Abstract
Abstract Background Meningococcal conjugate vaccine (MCV) programs in Canada began in 2002. Objectives This study examines the most recent surveillance data to describe the current Canadian epidemiology of invasive meningococcal disease (IMD) and the effect of MCV programs, especially on age and serogroup distribution. Design/Methods Active metropolitan area surveillance for hospitalization of adults and children due to IMD, which was defined as a clinical infection with Neisseria meningitidis isolated or detected by molecular methods or culture from a sterile body site. The study was conducted via the 12 centres of the Canadian Immunization Monitoring Program, Active (IMPACT) network from January 1, 2016 – December 31, 2020. Results During 2016-2020, a total of 105 pediatric (<20 years of age) and 145 adult IMD cases occurred. Serogroup B accounted for the greatest proportion of pediatric cases (N=58, 55.2%), followed by W (n=19, 18.1%) and Y (n=9, 8.6%) and C (n=2, 1.9%). Among adults, serogroup W accounted for the majority of cases (n=55, 38.0%), followed by Y (n=41, 28.3%), B (n=33, 22.8%) and C (n=7, 4.8%). The age distribution for serogroups covered by MCV programs has shifted to adults. The median age was 24.2 years (33.4 mean). Whereas the median age of serogroup B cases was 7.7 years (19.4 years mean) with 63.7% of cases occurring in children < 19 years of age and 46.2% in children 0-4 years of age. A total of 20 people died from meningococcal infections in 2016–2020. Five deaths were in children, four from serogroup B and one from serogroup W. Fifteen deaths were in adults, one from serogroup B, eight from serogroup W, three from serogroup Y, and three from Non-typeable/Other/Unknown serogroups. Conclusion Serogroup B, which is not covered by MCV programs, still accounts for the majority of pediatric IMD. Serogroup C has been controlled and rarely causes pediatric infection. With the implementation of MCV programs in children and adolescents, the median and mean age at infection has increased across all serogroups, except serogroup B. Serogroup W is still causing IMD among pediatric age groups.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.014 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.011 | 0.009 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.009 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".